Agradecimientos e Indicadores

Agradecimientos y financiamiento


El Centro de Microscopía Avanzada de la Región del BíoBío, CMA BIOBIO agradece a todos quienes han aportado a la creación y han sustentado el funcionamiento del Centro por casi 10 años.
 
Aportes Estatales
Programa de Investigación Asociativa PIA - ANID, proyecto ECM-12
Dirección Programa. Sra. Isabel Meneses

Aportes Institucionales
Universidad de Concepción
Rectoría Dr. Carlos Saavedra Rubilar
Rectoría Dr. Sergio Lavanchy Merino

Vicerrectoría. Dra. Andrea Rodríguez Tastets
Vicerrectoría. Dr. Bernabé Rivas Quiroz

Decanatura Fac. Cs. Biológicas, Dra. Soraya Gutiérrez Gallegos
Decanatura Fac. Cs. Biológicas, Dr. Nelson Carvajal Baeza

Aportes Investigadores/as

Dr. Fernando Martínez (aporte estereomicroscopio)
Dra. Romina Bertinat (aporte MAGPIX)
Dra. Katterine Salazar (aporte gabinete bioseguridiad)
Dra. María Inés Barría (aporte ACDU para FACSARIA III, BD)
Dra. Katherine Forman (aporte Cámara Microscopio / NanoDrop)

Indicadores relativos al quehacer del Centro


 

Principales Papers publicados usando tecnologías del CMA BIOBIO

 

Todas las Publicaciones

1) Beratto-Ramos, A., Agurto-Muñoz, C., Vargas-Montalba, JP., Castillo, R. Fourier-transform infrared imaging and multivariate analysis for direct identification of principal polysaccharides in brown seaweeds. Carbohydrate Polymers 230 (2020) 115561. https://doi.org/10.1016/j.carbpol.2019.115561
2) Ferrada, L., Barahona, MJ., Salazar, K., Nualart, F. Vitamin C controls neuronal necroptosis under oxidative stress. Redox Biol. 2020 Jan;29:101408 . doi: 10.1016/j.redox.2019.101408
3) Rojas, S., Basualto, E., Valdivia, L., Vallejos, N., Ceballos, K., Peña, E., Rivas, C., Nualart, F., Guzmán-Gutiérrez, E., Escudero, C., Toledo, F., Sobrevia, L., Cid, M., González, M. The acticity of IKCa and BKCa channels contributes to insulin-mediated NO synthesis and vascular tone regulation in human umbilical vein. Nitrid Oxide, 2020 Jun 1;99:7-16 doi: 10.1016/j.niox.2020.03.004
4) Torres-Vergara, P., Ho, YS., Espinoza, F., Nualart, F., Escudero, C., Penny, J. The constitutive androstane receptor and pregnane X receptorr in the brain. Br J Pharmacol 2020 Mar 22. doi: 10.1111/bph.15055
5) Araya, J., Carneiro, R., Freer, J., Neira, J., Castillo, R. Fourier transform infrared imaging and quantitative analysis of pre-treated Wood fibers: A comparision between partial least squares and multivariate curve resolution with alternating least squares methods in a case study. Chemometrics and Intelligent Laboratory Systems 195 (2019) 103890. https://doi.org/10.1016/j.chemolab.2019.103890
6) Bastidas, C., von Plessing, C., Troncoso, J., Sanhueza, M., Neira, J., Castillo, R. Analytical strategies based on near infrared spectroscopy and multivariate calibration for rapid quantification of florfenicol at low-concentrations in medicated-feed pellets. Microchemical Journal 147 (2019) 1068-1074. https://doi.org/10.1016/j.microc.2019.04.033
7) Ferrada, L., Salazar, K., Nualart, F. Metabolic control by dehydroascorbic acid: Questions and controversies in cancel cells. Journal of Cellular Physiology 2019;1-8. DOI: 10.1002/jcp.28637
8) Ferrada, L., Barahona, MJ., Salazar, K., Vandenabeele, P., Nualart, F. Vitamin C controls neuronal necroptosis under oxidative stress. Redox Biology. https://doi.org/10.1016/j.redox.2019.101408
9) Gavilán, J., Mennickent, D., Ramírez-Molina, O., Triviño, S., Pérez, C., Silva-Grecchi, T., Godoy, P., Becerra, J., Aguayo, L., Moraga-Cid, G., San Martín, V., Yévenes, G., Castro, P., Guzmán, L., Fuentealba, J. 17 Oxo Sparteine and Lupamine, Obtained from Cytisus scoparius, exert a neuroprotection against soluble oligomers of Amyloid-β toxicity by nicotinic acetylcholine receptors. Journal of Alzheimer’s Disease 67 (2019) 343-356. DOI 10.3233/JAD-180945
10) Martínez, F., Cifuentes, M., Tapia, JC., Nualart, F. The median eminence as the hypothalamic area involved in rapid transfer of glucose to the brain: functional and cellular mechanisms. Journal of Molecular Medicine. doi.org/10.1007/s00109-019-01799-5
11) Mella, J., Pérez, V., Zelada, Z., Moreno, N., Ionescu, A., Perlson, E., Henríquez, JP. Efficient gene transfer into primary muscle cells to analyse nerve-independent postsynaptic organization in vitro. Neuromuscul Disord. doi: 10.1016/j.nmd.2019.05.005
12) Muñoz, B., Gallegos, S., Peters, C., Murath, P., Lovinger, D., Homanics, G., Aguayo, L. Influence of nonsynaptic α1 glycine receptors on ethanol consumption and place preference. Addiction Biology. 2019;1-14. DOI: 10.1111/adb.12726
13) Pérez, V., Bermedo-García, F, Zelada, D., Court, F., Pérez, MA., Fuenzalida, M., Ábrigo, J., Cabello-Verrugio, C., Moya-Alvadaro, G., Tapia, JC., Valenzuela, V., Hetz, C., Bronfman, F., Henríquez, JP. The p75 NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability. Acta Neuropathologica Communications (2019) 7:147. https://doi.org/10.1186/s40478-019-0802-7
14) Pinto, C., Medinas, DB., Fuentes-Villalobos, F., Maripillán, J., Castro, AF., Martínez, AD., Osses, N., Hetz, C., Henríquez, JP. β-catenin aggregation in models of ALS motor neurons: GSK3β inhibition effect and neuronal differentiation. Neurobiol Dis (2019) 130:104497. doi:10.1016/j.nbd.2019.104497
15) Ulloa, V., Saldivia, N., Ferrada, L., Salazar, K., Martínez, F., Silva-Álvarez, C., Magdalena, R., Oviedo, MJ., Montecinos, H., Torres-Vergara, P., Cifuentes, M., Nualart, F. Basal Sodium-Dependet Vitamin C Transporter 2 polarization in choroid plexus explant cells in normal or scorbutic conditions. Scientific Reports (2019)9:14422. https://doi.org/10.1038/s41598-019-50772-2
16) Westermeier, F., Holyoak, T., Gatica, R., Martínez, F., Negrón, M., Yáñez, A., Nahmias, D., Nualart, F., Burbulis, I., Bertinat, R. Cytosolic phosphoenolpyruvate carboxykinase is expressed an α-cells from human and murine pancreas. J Cell Physiol. 2019;1-10. DOI:10.1002/jcp.28955
17) Westermier, F., Holyoak, T., Asenjo, J., Gatica, R., Nualart, F., Burbulis, I., Bertinat, R. Gluconeogenenic enzymes in β-Cells: Pharmacological targets from improving insulin secretion. Trends in Endrocrinology & Metabolism, Month 2019, Vol xx, No. xx. https://doi.org/10.1016/j.tem.2019.05.004
18) Barahona, MJ., Llanos, P., Recabal, A., Escobar-Acuña, K., Elizondo-Vega, R., Salgado, M., Órdenes, P., Uribe, E., Sepúlveda, F., Araneda, R., García-Robles, MA. Glial hypothalamic inhibition of GLUT2 expression alters satiety, impacting eating behavior. Glia 2018 (66)592-605. DOI: 10.1002/glia.23267
19) Bastidas, C., von Plessing, C., Troncoso, J., Castillo, R. Evaluation of the microscopic distribution of florfenicol in feed pellets for salmon by Fourier Transform infrared imaging and multivariate analysis. Journal of Pharmaceutical and Biomedical Analysis 152 (2018) 257-263. https://doi.org/10.1016/j.jpba.2018.02.002
20) Bermedo-García, F., Ojeda, J., Méndez-Olivos, E., Marcellini, S., Larraín, J., Henríquez, JP. The neuromuscular junction of Xenopus tadpoles: Revisiting a classical model of early synaptogenesis and regeneration. Mechanisms of Development 2018. https://doi.org/10.1016/j.mod.2018.05.008
21) Bertinat, R., Westermeier, F., Gatica, R., Nualart, F. Sodium tungstate: Is it a safe option for a chronic disease setting, such as diabetes? J. Cell Physiol. 2019;234:51-60. DOI: 10.1002/jcp.26913
22) Bertinat, R., Westermeier, F., Silva, P., Gatica, R., Oliveira, JM., Nualart, F., Gomis, R., Yáñez, A. The Antidiabetic Agent Sodium Tungstate Induces Abnormal Glycogen Accumulation in Renal Proximal Tubules from Diabetic IRS2-Knockout Mice. Journal of Dibetes Research 2018. https://doi.org/10.1155/2018/5697970
23) Cifuentes, M., Baeza, V., Arrabal, PM., Visser, R., Grondona, JM., Saldivia, N., Martínez, F., Nualart, F., Salazar, K. Expression of a Novel Ciliary Protein, IIIG9, during the differentiation and maturation of ependymal cells. Mol. Neurobiol. (2018) 55:1652-1664. DOI 10.1007/s12035-017-0434-5
24) Díaz, E., Elgueta, E., Sánchez, S.A., Barberá, J., Vergara, J., Parra, M., Dahrouch, M. Hybrid photoluminescent materials containing a benzobisthiazole core, towards liquid cristal and gel applications. Soft Matter (2017) 13:1804-1815. DOI 10.1039/C6SM02650H
25) Fernández-Pérez, E., Sepúlveda, F., Peters, C., Bascuñán, D., Riffo-Lepe, N., González-Sanmiguel, J., Sánchez, S., Peoples, R., Vicente, B., Aguayo, L. Effect of cholesterol on membrane fluidity and association of Aβ Oligomers and subsequent neuronal damage: A Double-Edge Sword. Front. Aging Neurosci. 10:226. doi: 10.3389/fnagi.2018.00226
26) González-Ramírez, M., Gavilán, J., Silva-Grecchi, T., Cajas-Madriaga, D., Triviño, S., Becerra, J., Saez-Orellana, F., Pérez, C., Fuentealba, J. A Natural Benzofuran from the patagonic Aleurodiscus vitellinus fungus has potent neuroprotective propierties on a ancer r model of Amyloid-β peptide toxicity. Journal of Alzheimer’s Disease 61 (2018) 1463-1475. DOI 10.3233/JAD-170958
28) Hepp, M., Escobar, D., Farkas, C., Hermosilla, V., Álvarez, C., Amigo, R., Gutiérrez, J., Castro, A., Pincheira, R. A Trichostatin A (TSA)/Sp1-mediated mechanism for the regulation of SALL2 tumor suppressor in Jurkat T cells. Gene Regulatory Mechanisms (2018). https://doi.org/10.1016/j.bbagrm.2018.05.002
29) Hermosilla, V., Salgado, G., Riffo, E., Escobar, D., Hepp, M., Farkas, C., Galindo, M., Morín, V., García-Robles, MA., Castro, A., Pincheira, R. SALL2 represses cyclins D1 and E1 expression and restrains G1/S cell cycle transition and ancer-related phenotypes. Molecular Oncology 12 (2018) 1026-1046. DOI: 10.1002/1878-0261.12308
30) López-Gambero, A.J., Martínez, F., Salazar, K., Cifuentes, M., Nualart, F. Brain glucose-sensing mechanism and energy homeostasis. Molecular Neurobiology 2018. https://doi.org/10.1007/s12035-018-1099-4
31) Mellado, C., Figueroa, T., Báez, R., Castillo, R., Melendrez, M., Schulz, B., Fernández, K. Development of graphene oxide composite aerogel with proanthocyanidins with hemostatic properties as a delivery system. ACS Appl. Mater. Interfaces 2018, 10, 7717-729. DOI 10.1021/acsami.7b16084
32) Muñoz, B., Yevenes, G., Förstera, B., Lovinger, D., Aguayo, L. Presence of inhibitory Glycinergic Transmission in Medium Spiny Neurons in the Nucleus Accumbens. Front. Mol. Neurosci. 11:228. doi: 10.3389/fnmol.2018.00228
33) Muñoz, D., Castillo, H., Henríquez, JP., Marcellini, S. Bone regenaration after traumatic skull injury in Xenopus tropicalis. Mechanisms of Development (2018). https://doi.org/10.1016/j.mod.2018.06.007
34) Oyarce, K., Silva-Álvarez, C., Ferrada, L., Martínez, F., Salazar, K., Nualart. F. SVCT2 is expressed by cerebellar precursor cells, which differentiate into neurons in response to ascorbic acid. Mol. Neurobiol. (2018) 55:1136-1149. DOI 10.1007/s12035-016-0366-5
35) Rosú, S., Toledo, L., Urbano, B., Sánchez, S., Calabrese, G., Tricerri, M.A. Learning from synthetic models of extracellular matrix; differential binding of wild type and amyloidogenic human apolipoprotein A-I to hydrogels formed from molecules having charges similar to those found in natural GAGs. Protein J. (2017) 36:374-383. DOI 10.1007/s10930-017-9728-8
36) Sáez-Orellana, F., Fuentes-Fuentes, M., Godoy, P., Silva-Grecchi, T., Panes, J., Guzmán, L., Yévenes, G., Gavilán, J., Egan, T., Aguayo, L., Fuentealba, J. P2X receptor overexpression induced by soluble oligomers of amyloid beta peptide potentiates synaptic failure and neuronal dyshomeostasis in cellular models of Alzheimer's disease. Neuropharmacology 128 (2018) 366-378. https://doi.org/10.1016/j.neuropharm.2017.10.027
37) Toledo, L., Racine, L., Pérez, V., Henríquez, JP., Auzely-Velty, R., Urbano, B. Physical nanocomposite hydrogels filled with low concentrations of TiO2 nanoparticles: Swelling, networks parameters and cell retention studies. Materials Science & Engineering C92 (2018) 769-778. https://doi.org/10.1016/j.msec.2018.07.024
38) Caviedes, A., Varas-Godoy, M., Lafourcade, C., Sandoval, S., Bravo-Alegría, J., Kaehne, T., Massmann, A., Figueroa, J., Nualart, F., Wyneken, U. Endothelial Nitric Oxide Synthase is present in dendritic spines of neurons in primary cultures. 2017. Front. Cell. Neurosci. 11:180. Doi:10.3389/fncel.2017.00180
39) Cifuentes, M., Baeza, V., Arrabal, P., Visser, R., Grondona, J., Salvivia, N., Martínez, F., Nualart, F., Salazar, K. Expression of a Novel Ciliary Protein, IIIG9, during the differentiation and maturation of ependymal cells. Mol Neurobiol. 2017 Feb.13.ISSN:1559-1182. doi=10.1007/s12035-017-0434-5
40) Fernández-Pérez, E., Sepúlveda, F., Peoples, R., Aguayo, L. Role of membrane GM1 on early neuronal membrane action of Aβ during onset of Alzheimer’s disease. Mol. Basis of Disease 1863 (2017) 3105-3116. DOI: 10.1016/j.bbadis.2017.08.013
41) Forman, K., Martínez, F., Cifuentes, M., Bertinat, R., Salazar, K., Nualart, F. Aging selectively modulates vitamin C transporter expression patterns in the kidney. J. Cell. Physiol. 232: 2418–2426, 2017. DOI: 10.1002/jcp.25504
42) Förstera, B., Muñoz, B., Lobo, M.K., Chandra, R., Lovinger, D.M. and Aguayo, L. Presence of ethanol- sensitive glycine receptors in medium spiny neurons in the mouse nucleus accumbens. J. Physiol 595.15 (2017) pp 5285-5300. DOI: 10.1113/JP273767
43) Oyarce, K., Silva-Álvarez, C., Ferrada, L., Martínez, F., Salazar, K., Nualart, F. SVCT2 is expressed by cerebellar precursos cells, which differentiate into neurons in response to ascorbic acid. Mol Neurobiol. 2017 Jan.17.ISSN:1559-1182. doi=10.1007/s12035-016-0366-5
44) Paillamanque, J., Sánchez-Tusie, A., Carmona, E., Treviño, C., Sandoval, C., Nualart, F., Osses, N., Reyes, J. Arachidonic acid triggers [Ca2+]I increases in rat round spermatids by a likely GPR activation, ERK signaling and ER/acid compartments Ca2+ release. 2017 PLoS ONE 12(2):e0172128. doi:10.1371/journal.pone.0172128
45) Pinzón-Daza, M., Cuellar-Saens, Y., Nualart, F., Ondo-Mendez, A., del Riesgo, L., Castillo-Rivera, F., Garzón, R. Oxidative stress promotes dexorubicin-induced Pgp and BCRP expression in colon cáncer cells under hypoxic conditions. J Cell Biochem. 2017 Jul;118(7):1868-1878. doi: 10.1002/jcb.25890
46) Racordon, D., Valdivia, A., Mingo, G., Erices, R., Aravena, R., Santoro, F., Bravo, M., Ramirez, C., González, P., Sandoval, A., González, A., Retamal, C., Kogan, M., Kato, S., Cuello, M., Osorio, G., Nualart, F., Álvarez, P., Gago-Arias, A., Fabri, D., Espinoza I., Sánchez, B., Corvalán, A., Pinto, M., Owen, G. Structural and functional identification of vasculogenic mimicry in vitro. Sci Rep. 2017 Aug 1;7(1):6985. doi: 10.1038/s41598-017-07622-w
47) Salazar, K., Martínez, F., Pérez-Martín, M., Cifuentes, M., Trigueros, L., Ferrada, L., Espinoza, F., Saldivia, N., Bertinat, R., Forman, K., Oviedo, MJ., López-Gambero, A., Bonansco, C., Bongarzone, E., Nualart, F. SVCT2 expression and function in reactive astrocytes is a common event in different brain pathologies. Mol. Biol. 2017. DOI 10.1007/s12035-017-0762-5
48) Uranga, R., Millán, C., Barahona, M., Recabal, A., Salgado, M., Martínez, F., Órdenes, P., Elizondo-Vega, R., Sepúlveda, F., Uribe, E., García-Robles, M. Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior. Sci Rep. 2017 Jun 16;7(1):3697. doi: 10.1038/s41598-017-03928-x
49) Luciano Ferrada, Katterine Salazar and Francisco Nualart Santander (2017). Vitamin C Transporter (SVCT2) Distribution in Developing and Adult Brains, Vitamin C, Associate Prof. Amal Hamza (Ed.), InTech, Available from: https://goo.gl/4ydnd4 DOI: 10.5772/intechopen.69055
50) Bertinat, R., Westermeier, F., Silva, P., Shi J., Nualart, F., Li X., Yáñez, A. Anti-Diabetic agent sodium tungstate induces the secretion of pro- and anti-inflammatory cytokines by human kidney cells. J Cell Physiol. 2017 Feb;232(2):355-362. doi: 10.1002/jcp.25429
51) Bertinat, R., Nualart, F. and Yáñez, A. SGLT2 inhibitors: Glucotoxicity and tumorigenesis downstream the renal proximal tube? J Cell Physiol. 2016 Aug;231(8):1635-7. doi: 10.1002/jcp.25286
52) Cuba-Díaz, M., Cerda, G., Rivera C., Gómez, A. Genome size comparision in Colobanthus quitensis populations show differences in species ploidy. Polar Biol (2016). doi:10.1007/s00300-016-2058-z
53) Campos, T., Ziehe, J., Palma, M., Escobar, D., Tapia, C., Pincheira, R., Castro, A. Rheb promotes cancer cell survival through p27Kip1-dependent activation of autophagy. Mol Carcinog. 2016 Feb;55(2):220-9. doi: 10.1002/mc.22272
54) Campos, T., Ziehe, J., Fuentes-Villalobos, F., Riquelme, O., Peña, D., Troncoso, R., Lavandero, S., Morin, V., Pincheira, R., Castro, A. Rapamycin requieres AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival. Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1200-7. doi: 10.1016/j.bbamcr.2016.03.009.
55) Cabrera, L., Saavedra, A., Rojas, S., Cid, M., Valenzuela, C., Gallegos, D., Careaga, P., Basualto, E., Haensgen, A., Peña, E., Rivas, C., Vera. J., Gallardo, V., Zúñiga, L., Escudero, C., Sobrevia, L., Wareing, M., González, M. Insulin induces relaxation and decreases hydrogen peroxide-induced vasoconstruction in human placental vascular bed in a mechanism mediated by calcium-activated potassium channels and L-Arginine/Nitric Oxide Pathways. Front Physiol. 2016 Nov 22;7:529. https://doi.org/10.3389/fphys.2016.00529
56) Bravo, S., Parra, M., Castillo, R., Sepúlveda, F., Turner, A., Bertin, A., Osorio, G., Tereszczuk, J., Bruna, C., Hasbún, R. Reversible in vivo cellular changes occur during desiccation and recovery: Desiccation tolerance of the resurrection filmy fern Hymenophyllum dentatum Cav. Gayana Bot. 73(2), 402-413, 2016. http://dx.doi.org/10.4067/S0717-66432016000200402
57) Elizondo-Vega, R., Cortés-Campos, C., Barahona, M., Carril, C., Ordenes, P., Salgado, M., Oyarce, K., García-Robles, M. Inhibition of hypotalamic MCT1 expression increases food intake and alters orexigenic and anorexigenic neuropeptide expression. Sci Rep. 2016 Sep 28;6:33606. doi: 10.1038/srep33606.
58) Fritz, A., Bertin, A., Hanna, P., Nualart, F., Marcellini, S. A single chance to contact multiple targets: Distinct osteocyte morphotypes shed light on the cellular mechanism ensuring the robust formation of osteocytic networks. J Exp Zool B Mol Dev Evol. 2016 Jul;326(5):280-9. doi: 10.1002/jez.b.22683.
59) Forman, K., Martínez, F., Cifuentes, M., Bertinat, R., Salazar, K., Nualart, F. Aging selectively modulates vitamin C transporter expression patterns in the kidney. J Cell Physiol. 2016 Jul 27. doi: 10.1002/jcp.25504.
60) García-Krauss, A., Ferrada, L., Astuya, A., Salazar, K., Cisternas, P., Martínez, F., Ramíerez, E., Nualart, F. Dehydroascorbic acid promotes cell death in Neurons Under Oxidative Stress: a protective role for Astrocytes. Mol Neurobiol. 2016 Nov;53(9):5847-5863. doi: 10.1007/s12035-015-9497-3
61) García, D., Ordenes, P., Benitez, J., González, A., García-Robles, M., López, V., Carvajal, N., Uribe, E. Cloning of two LIMCH1 isoforms: characterization of their distribution in rat brain and their agmatinase activity. Histochem Cell Biol. 2016 Mar;145(3):305-13. doi: 10.1007/s00418-015-1389-0.
62) Peters, C., Sepúlveda, F., Fernández-Pérez, E., Peoples, R., Aguayo, L. The level of NMDA Receptor in the membrane modulates Amyloid-β association and perforation. J Alzheimers Dis. 2016 May 6;53(1):197-207. doi: 10.3233/JAD-160170.
63) Martínez, A., Catalán, A., Rojas, N., Torres, V., Acuña, M. In vitro effectiveness of a terpenic denture cleanser on old biofilm surfaces. J Prosthodont. 2016 Sep 6. doi: 10.1111/jopr.12531.
64) Peters, C., Bascuñán, D., Opazo, C., Aguayo, L. Differential membrane toxicity of Amyloid-β fragments by pore forming mechanisms. J Alzheimers Dis. 2016;51(3):689-99. doi: 10.3233/JAD-150896.
64) Silva-Álvarez, C., Salazar, K., Cisternas, P., Martínez, F., Liour, S., Jara, N., Bertinat, R., Nualart, F. Apical polatization of SVCT2 in apical radial glial cells and progenitors during brain development. Mol Neurobiol. 2016 Sep 5. doi: 10.1007/s12035-016-0081-2
65) Ramírez, V., Ramos-Fernández, E., Henríquez, J., Lorenzo, A., Inestrosa, N. Wnt-5a/Frizzled9 receptor signaling through the Gα0-Gβγ complex regulates dendritic spine formation. J Biol Chem. 2016 Sep 2;291(36):19092-107. doi: 10.1074/jbc.M116.722132.
66) Salazar, K., Martínez, M., Ulloa, V., Bertinat, R., Martínez, F., Jara, N., Espinoza, F., Bongarzone, E., Nualart, F. SVCT2 overxpression in neuroblastoma cells induces celular branching that is associated with ERK signaling. Mol Neurobiol. 2016 Dec;53(10):6668-6679. https://doi.org/10.1007/s12035-015-9553-z
67) Stanic, K., Saldivia, N., Förstera, B., Torrejón M., Montecinos, H., Caprile, T. Expression patterns of extracelular matrix proteins during posterior commissure development. Front Neuroanat. 2016 Sep 28;10:89. doi: 10.3389/fnana.2016.00089
68) Vidal, F., Vásquez, P., Díaz, C., Nova, D., Alderete, J., Guzmán L. Mechanism of PAMAM dendrimers internalization in hippocampal neurons. Mol Pharm. 2016 Oct 3;13(10):3395-3403. https://doi.org/10.1021/acs.molpharmaceut.6b00381
69) Vera, A., Recabal, A., Salvidia, N., Stanic, K., Torrejón, M., Montecinos, H., Caprile, T. Interaction between SCO-spondin and low density lipoproteins from embryonic cerebrospinal fluid modulates their roles in early neurogenesis. Front Neuroanat. 2015 May 28;9:72. doi: 10.3389/fnana.2015.00072.
70) Woehlbier, U., Colombo, A., Saaranen, M., Pérez, V., Ojeda, J., Bustos, F., Andreu, C., Torres, M., Valenzuela, V., Medinas, D., Rozas, P., Vidal, R., López-González, R., Salameh, J., Fernandez-Collemann, S., Muñoz, N., Matus, S., Armisen, R., Sagredo, A., Palma, K., Irrazabal, T., Almeida, S., González-Pérez, P., Campero, M., Gao, F., Henny, P., van Zundert, B., Ruddock, L., Concha, M., Henriquez, J., Brown, R., Hetz, C. ALS-linked protein disulfide isomerase variants cause motor dysfunction. EMBO J. 2016 Apr 15;35(8):845-65. doi: 10.15252/embj.201592224.
71) Bertinat R, Silva P, Mann E, Li X, Nualart F, Yáñez AJ. In vivo Sodium Tungstate Treatment Prevents E-Cadherin Loss Induced by Diabetic Serum in HK-2 Cell Line. J Cell Physiol. 2015 Feb 28. doi: 10.1002/jcp.24974.
72) Castillo R del P, Araya J, Troncoso E, Vinet S, Freer J. Fourier transform infrared imaging and microscopy studies of Pinus radiata pulps regarding the simultaneous saccharification and fermentation process. Anal Chim Acta. 2015 Mar 25;866:10-20. https://doi.org/10.1016/j.aca.2015.01.032
73) Gatica R, Bertinat R, Silva P, Kairath P, Slebe F, Pardo F, Ramírez MJ, Slebe JC, Campistol JM, Nualart F, Caelles C, Yáñez AJ. Over-expression of muscle glycogen synthase in human diabetic nephropathy. Histochem Cell Biol. 2015 Mar;143(3):313-24. https://doi.org/10.1007/s00418-014-1290-2
74) Bertin A, Hanna P, Otarola G, Fritz A, Henriquez JP, Marcellini S. Cellular and molecular characterization of a novel primary osteoblast culture from the vertebrate model organism Xenopus tropicalis. Histochem Cell Biol. 2015 Apr;143(4):431-42. doi: 10.1007/s00418-014-1289-8
75) Pacheco CR, Morales CN, Ramírez AE, Muñoz FJ, Gallegos SS, Caviedes PA, Aguayo LG, Opazo CM. Extracellular α-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane. J Neurochem. 2015 Mar;132(6):731-41. doi: 10.1111/jnc.13060
76) Peters C, Espinoza MP, Gallegos S, Opazo C, Aguayo LG. Alzheimer's Aβ interacts with cellular prion protein inducing neuronal membrane damage and synaptotoxicity. Neurobiol Aging. 2015 Mar;36(3):1369-77. https://doi.org/10.1016/j.neurobiolaging.2014.11.019
77) Muñoz G, Urrutia JC, Burgos CF, Silva V, Aguilar F, Sama M, Yeh HH, Opazo C, Aguayo LG. Low concentrations of ethanol protect against synaptotoxicity induced by Aβ in hippocampal neurons.Neurobiol Aging. 2015 Feb;36(2):845-56. doi: 10.1016/j.neurobiolaging
78) Campos T, Ziehe J, Palma M, Escobar D, Tapia JC, Pincheira R, Castro AF. Rheb promotes cancer cell survival through p27Kip1-dependent activation of autophagy. Mol Carcinog. 2015. https://doi.org/10.1002/mc.22272
79) Bertinat R, Nualart F, Li X, Yáñez AJ, Gomis R. Preclinical and Clinical Studies for Sodium Tungstate: Application in Humans. J Clin Cell Immunol. 2015 Feb;6(1). pii: 285. doi: 10.4172/2155-9899.1000285
80) Álvarez-Ferradas C, Morales JC, Wellmann M, Nualart F, Roncagliolo M, Fuenzalida M, Bonansco C. Enhanced astroglial Ca2+ signaling increases excitatory synaptic strength in the epileptic brain. Glia. 2015 May 15. doi: 10.1002/glia.22817.
81) Astuya A, Carrera C, Ulloa V, Aballay A, Núñez-Acuña G, Hégaret H, Gallardo-Escárate C. Saxitoxin Modulates Immunological Parameters and Gene Transcription in Mytilus chilensis Hemocytes. Int. J. Mol. Sci. 2015, 16(7), 15235-15250; doi:10.3390/ijms160715235.
82) Sepúlveda FJ, Fierro H, Fernández E, Castillo C, Peoples RW, Opazo C, Aguayo LG. Nature of the neurotoxic membrane actions of amyloid-B on hippocampal neurons in Alzheimer´s disease. Neurobiol Aging. 2014 Mar; 35(3):472-81. doi: 10.1016/j.neurobiolaging
83) Mariqueo T., Agurto A, Muñoz B, San Martín L., Coronado C., Fernández-Pérez F., Murath P., Sánchez A, Homantics G., Aguayo LG. Effects of ethanol on glycinergic synaptic currents in mouse spinal cord neurons. J. Neurophysiol. Published 26 February 2014. doi: 10.1152/jn.00789
84) Cisternas P., Silva-Álvarez C., Martínez F., Fernández E., Ferrada L., Oyarce K., Salazar K., Bolaños JP., Nualart F. The oxidized form of vitamin C, dehydroascorbic acid, regulates neuronal energy metabolism. J. Neurochem. Jan 25, 2014. doi: 10.1111/jnc.12663
85) Oyarce K., Bongarzone E., Nualart, F. Unconventional neurogenic niches and neurogenesis modulation by vitamins. Stem Cell Research and Therapy. 4. 3-10. 2014. doi: 10.4172/2157-7633.1000184
86) Salgado M, Tarifeño-Saldivia E, Ordenes P, Millan C, Yañez MJ, Llanos P, Villagra M, Elizondo-Vega R, Martinez R, Nualart F, Uribe E, Garcia-Robles MA. Dynamic localization of glucokinase and its regulatory protein in hypothalmaic tanycytes. PLoS One. 2014; 9(4):e94035. https://doi.org/10.1371/journal.pone.0094035
87) Retamal M, Alcayaga J, Bultynck G, Leybaer L, Saez P, Fernandez R, Leon L, Saez J. The opening of connexin and pannexin hemichannels increases the excitability of nodose ganglion sensory neurons. Front Cell Neurosci. 2014 Jun 20;8:158. doi: 10.3389/fncel.2014.00158.
88) Araya JA, Ramírez AE, Figueroa-Aroca D, Sotes GJ, Pérez C, Becerra J, Saez-Orellana F, Guzmán L, Aguayo LG, Fuentealba J. Modulation of Neuronal Nicotinic Receptor by Quinolizidine Alkaloids Causes Neuroprotection on a Cellular Alzheimer Model . J Alzheimers Dis. 2014;42(1):143-55. doi: 10.3233/JAD-132045
89) Stanic K, Vera A, Gonzalez M, Recabal A, Astuya A, Torrejon M, Montecinos H, Caprile T. Complementary expression of EphA7 and SCO-spondin during posterior commissure development. Frontiers in Neuroanatomy.Front Neuroanat. 8:49, 2014. doi: 10.3389/fnana.2014.00049
90) Valdes P, Mercado G, Vidal R, Molina C, Parsons G, Court F, Martinez A, Galleguillos D, Armentano D, Schneider B, Hetz C. Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1. Proc Natl Acad Sci U S A. 2014 May 6;111(18):6804-9. doi: 10.1073/pnas.1321845111.
91) Salazar K, Cerda G, Martinez F, Sarmiento J, Gonzalez C, Rodriguez F, Garcia-Robles MA, Tapia JC, Cifuentes M, Nualart F. SVCT2 transporter expression is post-natally induced in cortical neurons and its function is regulated by its short isoform. J. Neurochem. J Neurochem. 130:693-709. 2014. doi: 10.1111/jnc.12793
92) Castro PA, Ramirez A, Sepúlveda FJ, Peters C, Fierro H, Waldron J, Luza S, Fuentealba J, Muñoz FJ, De Ferrari GV, Bush AI, Aguayo LG, Opazo CM. Copper-uptake is critical for the down regulation of synapsin and dynamin induced by neocuproine: modulation of synaptic activity in hippocampal neurons. Front Aging Neurosci. 2014 Dec 3;6:319. doi: 10.3389/fnagi.2014.00319
93) Morales JC, Alvarez-Ferradas C, Roncagliolo M, Fuenzalida M, Wellmann M, Nualart FJ, Bonansco C. A new rapid kindling variant for induction of cortical epileptogenesis in freely moving rats. Front Cell Neurosci. 2014 Jul 23;8:200. doi: 10.3389/fncel.2014.00200
94) Nualart, F., Mack, L., García, A., Cisternas, P., Borgarzone, ER., Heitzer, M., Jara, N., Martínez, F., Espinoza, F., Ferrada, L., Baeza, V., Salazar, K. Vitamin C transporters, recycling and the Bystander effect in the nervous system: SVCT2 versus GLUTs. Journal of Stem Cell Research and Therapy. 4(5):209. doi: 10.4172/2157-7633.1000209
95) Avilés EC, Pinto C, Hanna P, Ojeda J, Pérez V, De Ferrari GV, Zamorano P, Albistur M, Sandoval D, Henríquez JP. Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells. Front Cell Neurosci. 2014 Apr 17;8:110. doi: 10.3389/fncel.2014.00110
96) Fernández A, Guzmán S, Cruz Y, Zamorano P. Construction of bicistronic lentiviral vectors for tracking the expression of CDNF in transduced cells. Plasmid. 2014 Sep 10;76C:15-23. doi: 10.1016/j.plasmid
97) Zurita MP, Muñoz G, Sepúlveda FJ, Gómez P., Castillo C, Burgos CF, Fuentealba J, Opazo C, Aguayo LG. Ibuprofen Inhibits the Synaptic Failure Induced by the Amyloid-β Peptide in Hippocampal Neurons. J Alzheimers. 2013 Jan 1;35(3):463-73. doi: 10.3233/JAD-122314
98) Sandoval, D, Ojeda J, Low M, Nualart F, Marcellini S, Osses N, Henriquez JP (2013). The vitamin C transporter SVCT2 is down-regulated during postnatal development of slow skeletal muscles. Histochemistry and Cell Biology June 2013, Volume 139, Issue 6, pp 887-894. doi: 10.1007/s00418-012-1075-4
99) Cortes-Campos C, Elizondo R, Carril C, Martınez F, Boric K, Nualart F, Garcia MA. MCT2 Expression and Lactate Influx in Anorexigenic and Orexigenic Neurons of the Arcuate Nucleus. Plos One Vol 8 (4): e62532, 2013. doi: 10.1371/journal.pone.0062532
100) Ulloa V, García-Robles M, Martínez F, Salazar K, Reinicke K, Pérez F, Godoy DF, Godoy AS, Nualart F. Human choroid plexus papilloma cells efficiently transport glucose and vitamin C. J Neurochem. 2013 May 7. doi: 10.1111/jnc.12295.
101) Antileo E, Garri C, Tapia V, Muñoz JP, Chiong M, Nualart F, Lavandero S, Fernández J, Núñez MT. Endocytic pathway of exogenous iron-loaded ferritin in intestinal epithelial (Caco-2) cells. Am J Physiol Gastrointest Liver Physiol. 2013 Apr 1;304(7):G655-61. doi: 10.1152/ajpgi.00472
102) Vera A, Stanic K, Montecinos H, Torrejón M, Marcellini S, Caprile T. SCO-spondin from embryonic cerebrospinal fluid is required for neurogenesis during early brain development. Front Cell Neurosci. 2013 Jun 3,; Vol 7:80. doi: 10.3389/fncel.2013.00080
103) Peters. C, Fernandez-Perez E, Burgos C, Espinosa MP, Castillo C, Urrutia JC, Streltsov V, Opazo C, Aguayo L. Inhibition of amyloid beta-induced synaptotoxicity by a pentapeptide derived from the glycine zipper región of the neurotoxic peptide. Neurbiology of Aging 34 (2013) 2805-2814. doi: 10.1016/j.neurobiolaging
104) Pastor P, Cisternas P, Salazar K, Silva-Alvarez C, Oyarce K, Jara N, Espinoza F, Martinez A, Nualart F. SVCT2 vitamin C transporter expression in progenitor cells of the postnatal neurogenic niche. Front Cell Neurosci. 2013 Aug 13;7:119. doi:10.3389/fncel.2013.00119.
105) Pinto C, Cárdenas P, Osses N, Henríquez JP. Characterization of Wnt/β-catenin and BMP/Smad signaling pathways in an in vitro model of amyotrophic lateral sclerosis. Front Cell Neurosci. 2013 Dec 3; 7:239. https://doi.org/10.3389/fncel.2013.00239
106) Montoya F, Martínez F., García-Robles M., Balmaceda-Aguilera C., Koch X., Rodríguez F., Silva-Álvarez C., Salazar K., Ulloa V., Nualart F. Clinical and experimental approaches to knee cartilage lesión repair and mesenchymal stem cell chondrocyte differentiation. Biol. Res. 46 No 4, 2013. http://dx.doi.org/10.4067/S0716-97602013000400015
107) Reinicke, K., Sotomayor, P., Cisterna, P., Delgado, C., Nualart, F., Godoy A. (2012). Cellular distribution of GLUT1 and GLUT5 in beningn and malignant prostate tissue. Journal of Cellular Biochemistry 113:553-562. doi: 10.1002/jcb.23379
108) Orellana JA, Sáez P, Cortés-Campos C, Elizondo RJ, Shoji K, Contreras-Duarte S, Figueroa V, Velarde V, Jiang J, Nualart F, Sáez JC, García MA. Glucose increases intracellular free Ca(2+) in tanycytes via ATP released through connexin 43 hemichannels. GLIA 2012 60:53-68. doi: 10.1002/glia.21246
109) Balmaceda-Aguilera, C., Cortés-Campos, C., Cifuentes, M., Peruzzo, B., Mark, L., Tapia, JC., Oyarce, K., García, MA., Nualart, F. (2012). Glucose transporter 1 and monocarboxylates transporters 1, 2 and 4 localization within the glial cells of shark blood-brain-barrier. PlosOne 7:e32409. doi: 10.1371/journal.pone.0032409
110) Nualart F, Castro T, Low M, Henríquez JP, Oyarce K, Cisterna P, García A, Bertinat R, Yáñez A, Montecinos V, García-Robles MA. (2012). Dynamic expresión of the sodium-vitamin C cotransporters, SVCT1 and SVCT2, during perinatal development. Histochemistry and Cell Biology Sep 19. doi: 10.1007/s00418-012-1027-z
111) Gatica R, Bertinat R, Silva P, Carpio D, Ramírez MJ, Slebe JC, San Martín R, Nualart F, Campistol JM, Caelles C, Yáñez A. Altered expression and localization of insulin receptor in proximal tubule cells from human and rat diabetic kidney. J Cell Biochem. 2013 Mar;114(3):639-49. doi: 10.1002/jcb.24406.
112) Marcellini S, Henriquez JP, Bertin A. Control of osteogenesis by the canonical Wnt and BMP pathways in vivo: Cooperation and antagonism between the canonical Wnt and BMP pathways as cells differentiate from osteochondroprogenitors to osteoblasts and osteocytes. Bioessays 2012, 3(11):953-62. doi: 10.1002/bies.201200061
113) Benavente F. Pinto C., Parada M., Henriquez JP. Amd Osses N. Bone morphogenic protein 2 inhibits neurite outgrowth of motor neuron-like NSC-34 cells and up-regulates its type II receptor. J. Neurochem, 2012, 122 594-604. doi: 10.1111/j.1471-4159.2012.07795.x
114) Nualart F, Salazar K, Oyarce K, Cisternas P, Jara N, Silva-Alvarez C, Pastor P, Martínez F, García A, García-Robles MA, Tapia JC. (2012). Typical and atypical stem cells in the brain, vitamin C effect and neuropathology. Biol Res. 2012;45(3):243-56. http://dx.doi.org/10.4067/S0716-97602012000300006
115) Castro PA, Figueroa M, Yevenes GE, San Martin LS, Alguayo L. The basic property of Lys385 is important for potentiation of the human α1 glycine receptor by ethanol. J Pharmacol Expe. 2012; 340 (2): 339-49. doi: 10.1124/jpet.111.185140
116) Fuentealba J, Dibarrart A, Saez-Orellana F, Fuentes M.C., Oyanedel CN, Guzmán JL, Perez C, Becerra J, Aguayo L. Synaptic Sylencing and plasma membrane Dyshomeostasis Induced by Amyloid-b Peptide are Prevented by Aristotelia chilensis Enriched Extract. J. Alzheimer Disease 31 (2012): 879-889. doi: 10.3233/JAD-2012-120229

Otras Publicaciones.-


1) Racordon, D., Valdivia, A., Mingo, G., Erices, R., Aravena, R., Santoro, F., Bravo, M., Ramirez, C., González, P., Sandoval, A., González, A., Retamal, C., Kogan, M., Kato, S., Cuello, M., Osorio, G., Nualart, F., Álvarez, P., Gago-Arias, A., Fabri, D., Espinoza I., Sánchez, B., Corvalán, A., Pinto, M., Owen, G. Structural and functional identification of vasculogenic mimicry in vitro. Sci Rep. 2017 Aug 1;7(1):6985. doi: 10.1038/s41598-017-07622-w.
2) Woehlbier, U., Colombo, A., Saaranen, M., Pérez, V., Ojeda, J., Bustos, F., Andreu, C., Torres, M., Valenzuela, V., Medinas, D., Rozas, P., Vidal, R., López-González, R., Salameh, J., Fernandez-Collemann, S., Muñoz, N., Matus, S., Armisen, R., Sagredo, A., Palma, K., Irrazabal, T., Almeida, S., González-Pérez, P., Campero, M., Gao, F., Henny, P., van Zundert, B., Ruddock, L., Concha, M., Henriquez, J., Brown, R., Hetz, C. ALS-linked protein disulfide isomerase variants cause motor dysfunction. EMBO J. 2016 Apr 15;35(8):845-65. doi: 10.15252/embj.201592224.
3) Jara, N., Cifuentes, M., Martinez, F., Salazar, K., Nualart, F. Cytoarchitecture, proliferative activity and neuroblast migration in the subventricular zone and lateral ventricle extension on the adult guinea pig brain. Stem Cells. 2016 Oct;34(10):2574-2586. doi: 10.1002/stem.2430.
4) Mellado, C., Figueroa, T., Báez, R., Castillo, R., Melendrez, M., Schulz, B., Fernández, K. Development of graphene oxide composite aerogel with proanthocyanidins with hemostatic properties as a delivery system. ACS Appl. Mater. Interfaces 2018, 10, 7717-729. DOI 10.1021/acsami.7b16084.
5) Valdivia, A., Mingo, G., Aldana, V., Pinto, MP., Ramirez, M., Retamal, C., Gonzalez, A., Nualart, F., Corvalan, AH., Owen, GI. Fact or fiction, it is time for a veredic on vasculogenic mimicry?. Front Oncol. 2019 Aug 2,9:680. doi: 10.3389/fonc.2019.00680
es_ES
en_US es_ES